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KMID : 0385520150280050309
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Analytical Science & Technology
2015 Volume.28 No. 5 p.309 ~ p.316
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Validation of ICP-MS method for trace level analysis of Pb in plasma
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Lee Sung-Bae
Kim Yong-Soon
Lee Yong-Hoon
Ahn Byung-Joon
Kim Nam-Soo
Lee Byung-Kook
Shin Ho-Sang
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Abstract
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The analytical method of lead in plasma by ICP-MS was validated after securing environment within class 1,000 classification. We tested specificity and accuracy of within-run and between-run. According to measurement of the amount of suspended particulates in a clean room, 0.3~62 particles were detected in 0.3 μm size while 0.0~28.3 particles were observed in 0.5 μm size. Total suspended particulates met required environment with up to 90.3 particles. The MDL (Method detection limit) of the sample which has been fabricated using fetal bovine serum (FBS) blank was 1.77 ng/L, and LOQ (Limit of quantification) was 5.55 ng/L. The slope, intercept and correlation coefficient of the calibration curve were y
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KEYWORD
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validation, lead, plasma, inductively coupled plasma-mass spectrometry,
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